Brüno was born in 1975 in Germany.
His father served in the military while his mother was a housewife. After graduating from high school he spent a year at the Ecole Estienne in Paris, then moved to Rennes, where he obtained a master's degree in visual arts.
In 1996 his first works were noticed by the publishing house La Chose (Cranial Guide, Vitr Mo...).
He was signed by Treize Étrange in 1998, where he created Nemo, a loose adaptation of the Jules Verne novel Twenty Thousand Leagues Under the Sea.
From 2001, with Fatima Ammari-B, he published Inner City Blues, a crime drama that takes place in America's dark mid-1970s.
From 2003 to 2006 with Pascal Jousselin he created the artwork of Les aventures de Michel Swing, an improvised series carried out by the two of them. Before appearing as a print edition (Treize Étrange) in 2006, the cartoon was posted on the Internet.
In 2007 he met Apollo, with whom he was signed at Dargaud. Together they created two series — Biotope (a sci-fi diptych) and Commando colonial.
To this day he continues his successful collaborations at Dargaud, notably with Fabien Nury, with whom he co-created Atar Gull (Dargaud/Europe Comics, 2015).
In 2013, the two authors launched a new series, Tyler Cross (Dargaud/Europe Comics, 2015). The third volume, Miami, was released in March 2018 (April 2018 by Europe Comics).
Brüno lives and works in Nantes.